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Flutriafol Use
Aug 25, 2017

(1h-1,2,4-triazole-1-ylmethyl) diphenylmethanol IUPAC (English name) Flutriafol 【Chemical name】 2,4'-difluoro-α- Name (RS) -2,4'-difluoro-α (1H-1,2,4-triazol-1-ylmethyl) benzhydryl alcohol 【Melting point (℃)】 130 【Vapor pressure (Pa)】 7.1x 10-6 MPa (20 ℃) 【toxicity LD50 (mg / kg)】 rat acute oral LD50: male rats 1140, the number of words 1480; acute percutaneous greater than 1000. A slight irritation to the rabbit eyes. Experiments conducted in mammalian cells showed no mutagenicity. LC5061mg / L for carp and trout. Solvent (Solubility) Solubility (20 ~ 23 ℃); Water 130mg / L (pH 7, 20 ° C). Solubility in Organic Solvent (g / L :) Acetone in 190 , Methanol in 69, dichloromethane 150, xylene 12g / L. 【Uses】 Smectazol is a broad-spectrum within the fungicide, the Basidiomycetes and Ascomycetes caused by a variety of diseases have a good protection and treatment, can effectively control wheat crop powdery mildew, rust, black Disease, corn smut and so on. [Preparation or source] anhydrous potassium fluoride and 2,3,4,5-tetrachloronitrobenzene in anhydrous dimethylformamide at 140 ° C for 15 hours to produce 2,4-difluoro-3, 5-dichloronitrobenzene, followed by reduction reaction with iron powder at 95 to 100 ° C for 8 hours in acetic acid to give 2,4-difluoro-3,5-dichloroaniline. 2,6-difluorobenzamide was reacted with oxalyl chloride in toluene for 5 hours to give 2,6-difluorobenzoyl isocyanate, followed by treatment with the above-mentioned 2,4-difluoro-3,5-dichloro Aniline was reacted in toluene at room temperature for 15 hours to obtain a product. The present invention discloses a preparation method of a bactericidal agent, which comprises the following steps: firstly, from 1 - (2- (4-fluorophenyl) Fluorophenyl) -1- (4-fluorophenyl) oxirane and 1,2,4-triazole, solid base in the presence of a phase transfer catalyst, in a polar solvent to produce crude dioxazole; Finally, the use of new technology, the choice of effective organic solvents, dissolved cranidol crude, the use of benzodiazole alcohol and impurities in the solubility difference, first remove most of the impurities, and then pickling, washing and stratification, crystallization of more than 95% Oxazole alcohol products. The present invention minimizes the type and amount of the solvent required for the reaction and the amount of the reaction washing waste water to achieve the purpose of cleaning and safe production.